Long-term observation of biochemical effects of lead in human experiments.
نویسندگان
چکیده
In extension of two previous series of experiments, the results of which have been partially reported (1), further long-term tests were performed with daily oral doses of 5 mg Pb++ in 2 subjects. Lead in whole blood, free protoporphyrin 9 (III) and 5-aminolevulinate dehydratase activity in erythrocytes, hemoglobin, and urinary 5-aminolevulinic acid and coproporphyrin III excretion values were measured. From experiences with 8 human experiments, three compartmental phases of early detectable lead effect were postulated: 1. an "erythrocytic" reaction of 5-aminolevulinate dehydratase activity, 2. "hepatic" reactions of 5-aminolevulinic acid and coproporphyrin, and 3. an "erythropoietic" reaction of protoporphyrin.
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ورودعنوان ژورنال:
- Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie
دوره 17 4 شماره
صفحات -
تاریخ انتشار 1979